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Field
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”. They showed that the tumor microenvironment enforces the production of aberrant proteins in cancer cells (Bartok et al., Nature 2021; Champagne et al., Molecular Cell 2022; Pataskar et al., Nature 2022; Yang
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Transient protein-protein interactions (PPIs) control all cellular processes relevant to health and disease. Thus, a major problem in life-sciences research is to understand and manipulate PPIs with
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protein homeostasis which are important for a number of aging-related diseases, including neurodegeneration, and several forms of cancer. The research group of Professor Christian Kaiser , which just
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interventions against protein misfolding and perturbed protein homeostasis which are important for a number of aging-related diseases, including neurodegeneration, and several forms of cancer. The research group
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Primary supervisor - Dr Amit Sachdeva Secondary supervisor - Prof Andy Cammidge Over the last decade, several antibody-based biotherapeutics have been developed for treatment of cancer
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proteins in cancer and how protein misfolding and aggregation result in amyloids. Recent results have shown that amyloids formed by the protein alpha-synuclein, which is linked to Parkinson's disease, can
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Cancer Institute in Amsterdam has recently uncovered a novel phenomenon in cancer termed “Sloppiness”. They showed that the tumor microenvironment enforces the production of aberrant proteins in cancer
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important for human health and to counteract diseases. Current research directions include the role of copper-binding proteins in cancer and how protein misfolding and aggregation result in amyloids. Recent
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, named bioportides, are also biologically active and can themselves act as a drug. Of relevance to this project, selected bioportides which mimic important segments of proteins found throughout the animal
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Description Extracellular vesicles (EVs) have gained tremendous interest in recent years due to their myriad of potential applications in medicine, such as tissue regeneration, immune modulation, and cancer